40yr old with severe anemia

 A 40 yr old female came to hospital with chief complaint of Menorrhagia past 6months

HISTORY OF PRESENT ILLNESS:

A 40yr old female who was born out of consaginous marriage grade III through a normal vaginal delivery at her mother's sister house. She immediately cried and was breast  fed for 1year.

Her immunization is not known .

Since childhood she used to eat only one meal per day though she had a good appetite because of weakness. 

She used to sway side by side while walking,sometimes fell down and again she used to get up on her own.

She used to get ready to school by herself.(wearing uniform,combing hair)

She used to repeat her standard almost 2-3 times.

She attained menarche at the age of 14yrs with normal flow 4-5 days/month with no clots. LMP- 5/2/2022

Once she complained of heavy bleeding for a month for which they went to local mbbs doctor  who provided medications and her bleeding was relieved.

Now since 6 months ,she is having heavy bleeding per vagina during her cycles with clots for which they took medication which was prescribed earlier which was not relieved.

Then they went to local hospital where she was diagnosed as anemic and blood transfusion was suggested. But transfusion wasn't done due to unknown reasons.

Then she came to our hospital.

PEDIGREE CHART

PAST HISTORY:

Not a k/c/C/o DM, HTN, thyroid, epilepsy, asthma.

General examination

Patient is c/c/c thin built and malnourished

Pallor ++, 





no icterus, cyanosis, clubbing, edema

Temp-Afebrile

PR - 108bpm

BP-100/60 mmHg

Spo2 99%

GRBS - 87mg/dl

CVS

Inspection - 

JVP raised

Apical impulse diffuse in 5th and 6th IC space

Palpation - thrills and para sternal haeve +

            apex beat in mud clavicular line

Auscultation - loud S1 S2 + at pulmonary and tricuspid area , systolic murmer +

CNS Examination

PT - c/c non Co operative

MMSE 20/30

Speech normal

Cranial Nerve examination:

CN 1 Not done

CN 2 Normal pupillary reflex

CN 3, 4, 6 Upward and lateral eye movement restricted ( She was closing eyes)

CN 5 Weak

CN 7  Weak

CN 8,9,10,11,12 Not done as she was not co operative

Sensory examination Not done as uncooperative


Motor system


Tone - Rt Lt


U/L N N

L/L N N


Power 


U/L 4/5 _ 4/5

L/L 4/5 _ 4/5


Reflex   

    

Biceps 3+ 3+


Triceps 3+ 3+


Supinator 3+ 3+


Knee 3+ 3+


Ankle 3+ 3+


Plantar dorsiflexion

Romberg test:

https://youtu.be/YwIbnvArBlI




RS - BAE +

P/A - soft NON-TENDER 


 Her outside reports were : 

 HB- 2.3%

 Plt - 56,000

TLC - 7900

PCv - 8.2%

BGT - O +ve

Sr.cretinine- 1.4 mg/dl

Na+ - 139

CL - 96

K- 2.9

LFT 

TB - 1mg/dl

DB - 0.2,ID - 0.8

ALT - 27, AST - 28

ALP - 114

TP - 6.9

ALB - 3.3

GLB - 3.6



Investigations on 07/02/2022

ECG


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ECG ON 08/02/2022



Chest X ray
Usg
-Abdomen
No sonographical abnormalities detected
-neck
Diffuse thyroid disease with TIRADS-3 nodule in isthmus.

2D Echo
LFt
TB - 1.43
DB - 0.39
AST - 974
ALT 584
ALP - 66
TP - 5.2
ALB - 3.33,GLB - 1.95

RFT 
Na- 140
K - 3.9
Cl- 103
Urea - 30mg /dl
Cr - 0.9 mg /dl
Thyroid profile
T3-0.6
T4-10.72
TSH-4.16
CBP - 
CBP - 
HB- 1.7%
TLC - 13,100
N/L/E/M/B/- 81/06/03/10/0
PCB - 6.8%
MCV - 57.1
MCH- 14.3
MCHC-25
RDW-CV  - 28
RDW - SD - 56.5
RBC - 1.19 MILLION
PLT - 74,000
PERIPHERAL SMEAR.                                           
RBC - microcytic hypochromic with target cells, fragmented forms, pencil forms and severe anisopoikilocytosis
WBC - count increased, neutrophils show toxic granules
Impression - Microcytic hypochromic anaemia with neutrophilic leucocytosis and moderate thrombocytopenia. 

Reticulocyte count - 1.4%
LDH - 3027 IU/L

Diagnosis - Bicytopenia under evaluation
Rx
 1.inj TRANEXA 500MG IV stat
 2.inj pantop 40 mg iv/od
 3.inj zofer 4 mg iv/sos
 4. Plan for 1unit PRBC transfusion
 5. Monitor vitals 4th hrly
 6. I/o charting


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